Cell CyCle News & Views www.landesbioscience.com Cell Cycle 1661

The tumor suppressor p53 is a well-charac-terized regulator of energy metabolism. p53 transcriptionally regulates a number of major metabolic regulators such as 5 ′ AMP-activated protein kinase (AMPK) and regulators of AMPK including the sestrins, mTOR through TsC1/ TsC2, and glycolytic modulators such as TiGAR, hexokinase, and sCO2, which affect cellular oxidative stress.1 Moreover, p53 has 2 defined links to NAD+, a multifunctional cellular metabolite and coenzyme. First, the NAD+-dependent deacetylase sirtuin 1 (siRT1) has been shown to modify the p53 response through deacetylation of the p53 C terminus.2 second, p53 interacts with PARP1, an enzym