ORIGINAL RESEARCH ARTICLE The relationship between a t

es Obstructive Lung Disease (GOLD) COPD is "a disease state characterized by airflow limitation that is not fully tations such as weight loss, skeletal muscle dysfunction, an increased risk of cardiovascular disease, osteoporosis Agarwal et al. Multidisciplinary Respiratory Medicine 2013, 8:63 http://www.mrmjournal.com/content/8/1/63sponse to tissue damage or inflammation. It has beenMedical College, Aligarh Muslim University, Aligarh 202002, India Full list of author information is available at the end of the articlereversible. The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lungs to noxious particles and gases " [2]. For the first time this definition encompasses the idea that COPD is a chronic inflammatory disease and much of and depression, among others [3-6]. Blood markers, such as IL-6, CRP and fibrinogen have attracted interest during recent years, and further studies in this area will probably increase the understanding of systemic manifes-tations in COPD [7]. One of the inflammatory markers which is increasingly evaluated in COPD patients is C-reactive protein (CRP) [8]. C-Reactive Protein (CRP) is an acute phase protein synthesized predominantly by the hepatocytes in re-* Correspondence