Evaluation of a New Diagnostic Kit for the Enzymatic Determination of Creatinine

Summary: We have evaluated a new diagnostic kit for the enzymatic determination of creatinine in serum, plasma and urine. The method was found to be linear up to 1000 μπιοΐ/ΐ. Within-run precision had a coefficient of variation of 3.1-5.6 % for normal to slightly elevated values and of 2.3-3.3 % for values of about 320 μπιοΐ/ΐ. Day-to-day precision was found to be 7.8 and 5.7 % for values of 94 and 141 μπιοΐ/ΐ, respectively. Mean analytic recovery was 98 %. Bilirubin and hemoglobin did not interfere in concentrations up to 490 and 240 μιηοΐ/ΐ, respectively. The influence of lipids was studied. Correlation studies were done with two other methods, the Technicon SMA 12/60 method and the Dutch standard manual method. Evaluation eines neuen diagnostischen Reagenzbesteckes f r die enzymatische Bestimmung von Kreatinin Zusammenfassung: Ein neues diagnostisches Reagenzbesteck f r die enzymatische Bestimmung von Kreatinin i