References 1 Palmer, J.L. and Abeles, R.H. (1979) Mechanism of action of

Adenosine leads to the reduction of the tightly bound NADþ to NADH and to inhibition of the catalytic activity of AdoHcyase. Although adenosine and cAMP compete for the samebinding site at the enzyme, theydiffer in theirability to reduce the enzyme from the NADþ form to its NADH form. Correspondingly, cAMP does not inhibit but rather stimu-lates AdoHcyase. These binding sites suggest that AdoH-cyase might be modified by novel chemical entities