The nine membrane-bound isoforms of adenylyl cyclase (AC), via synthesis of the signaling molecule cyclic AMP (cAMP), are involved in many isoform specific physiological functions. Decreasing AC5 activity has been shown to have potential therapeutic benefit, including reduced stress on the heart, pain relief, and attenuation of morphine dependence and withdrawal behaviors. However, AC structure is well conserved, and there are currently no isoform selective AC inhibitors in clinical use. P-site inhibitors inhibit AC directly at the catalytic site, but with an uncompetitive or noncompetitive mechanism. Due to this mechanism and nanomolar potency in cell-free systems, attempts at ligand-based drug design of novel AC inhibitors frequently use ...
Thesis advisor: Charles HoffmanIn both mammals and fission yeast, control of cAMP levels is maintain...
Intracellular concentrations of the ubiquitous second messenger cyclic adenosine monophosphate (cAMP...
Adenylyl cyclases (ACs) catalyze the conversion of ATP into the second messenger cAMP and play a key...
The nine membrane-bound isoforms of adenylyl cyclase (AC), via synthesis of the signaling molecule c...
Nine membrane-bound adenylyl cyclase (AC) isoforms catalyze the production of the second messenger c...
Adenylyl cyclases (AC) is a critical family of enzymes which modulates the dynamic cellular level of...
We evaluated the efficacy, potency, and selectivity of the three most commonly used adenylate cyclas...
Adenylyl cyclase (AC) isoforms are implicated in several physiologic processes and disease states, b...
The nine membrane-bound isoforms of adenylyl cyclase (AC), via synthesis of the signaling molecule c...
Adenylyl cyclases (AC) catalyze the formation of cyclic AMP (cAMP) from ATP and are involved in a nu...
Adenylyl cyclase (AC) is an important messenger involved in G-protein-coupled-receptor signal transd...
Adenylyl cyclase type 5 (AC5) was described as major cardiac AC isoform. The knockout of AC5 (AC5KO)...
Adenylyl cyclases (ACs) generate the second messenger cAMP from ATP. Mammalian cells express nine tr...
Adenylyl cyclases (AC) are a major component of the cAMP signaling pathway. The differential regulat...
Adenylyl cyclase type 5 (AC5) was described as major cardiac AC isoform. The knockout of AC5 (AC5KO)...
Thesis advisor: Charles HoffmanIn both mammals and fission yeast, control of cAMP levels is maintain...
Intracellular concentrations of the ubiquitous second messenger cyclic adenosine monophosphate (cAMP...
Adenylyl cyclases (ACs) catalyze the conversion of ATP into the second messenger cAMP and play a key...
The nine membrane-bound isoforms of adenylyl cyclase (AC), via synthesis of the signaling molecule c...
Nine membrane-bound adenylyl cyclase (AC) isoforms catalyze the production of the second messenger c...
Adenylyl cyclases (AC) is a critical family of enzymes which modulates the dynamic cellular level of...
We evaluated the efficacy, potency, and selectivity of the three most commonly used adenylate cyclas...
Adenylyl cyclase (AC) isoforms are implicated in several physiologic processes and disease states, b...
The nine membrane-bound isoforms of adenylyl cyclase (AC), via synthesis of the signaling molecule c...
Adenylyl cyclases (AC) catalyze the formation of cyclic AMP (cAMP) from ATP and are involved in a nu...
Adenylyl cyclase (AC) is an important messenger involved in G-protein-coupled-receptor signal transd...
Adenylyl cyclase type 5 (AC5) was described as major cardiac AC isoform. The knockout of AC5 (AC5KO)...
Adenylyl cyclases (ACs) generate the second messenger cAMP from ATP. Mammalian cells express nine tr...
Adenylyl cyclases (AC) are a major component of the cAMP signaling pathway. The differential regulat...
Adenylyl cyclase type 5 (AC5) was described as major cardiac AC isoform. The knockout of AC5 (AC5KO)...
Thesis advisor: Charles HoffmanIn both mammals and fission yeast, control of cAMP levels is maintain...
Intracellular concentrations of the ubiquitous second messenger cyclic adenosine monophosphate (cAMP...
Adenylyl cyclases (ACs) catalyze the conversion of ATP into the second messenger cAMP and play a key...