Research Article CODEN: IJPNL6 PHYTOCHEMICAL SCREENINGS, MEMBRANE STABILIZING ACTIVITY, THROMBOLYTIC ACTIVITY AND CYTOTOXIC PROPERTIES OF LEAF EXTRACTS OF MIMOSA PUDICA

In this present study, the leaf extracts of Mimosa pudica were subjected to a comparative evaluation of the membrane stabilization, thrombolytic and cytotoxic activity to brine shrimps (Artemia salina). The thrombolytic and membrane stabilizing activities were assessed by using human erythrocyte and the results were compared with standard streptokinase (SK) and standard anti-inflammatory drug, acetyl salicylic acid (ASA), respectively. The extracts demonstrated significant toxicity to A. salina with LC50 values ranging from 1.58 to 3.38 μg/ml as compared to standard vincristine sulphate (VS, LC50value 0.92 μg/ml). Preliminary phytochemical investigation suggested the presence of carbohydrates, flavonoids, glycosides and steroids. Key words: Mimosa pudica, thrombolytic activity, membrane stabilization, cytotoxic propertie