Research Article CODEN: IJPNL6 IN VITRO ANTIOXIDANT ACTIVITIES AND IN VIVO ANTI-NOCICEPTIVE AND NEUROPHARMACOLOGICAL ACTIVITIES OF MIMOSA PUDICA

Mimosa pudica is the herb that shows sensation on touch. It has been identified as Lajjalu in Ayurveda and has been found to have anti-asthmatic, aphrodisiac, analgesic, anti- inflammatory and antidepressant activities. The aim of this study was to evaluate in-vitro antioxidant activity and in vivo biological activity considering anti-nociceptive assessment & neuropharmacological study include open field and swimming test. There is no scientific report on analgesic activity and neuropharmacological activity of Mimosa pudica, therefore the present study was undertaken to examine the possible in-vitro antioxidant activity of the extracts of Mimosa pudica was performed using DPPH free radical scavenging, cupric reducing antioxidant capacity, total antioxidant capacity, total phenol and total flavonoid content determination assays. The result of tests for in-vitro antioxidant activity indicates that petroleum ether extract shows maximum antioxidant activity. This plants leaf extracts also exhibit significant anti-nociceptive activity and neuropharmacological activity. Key words: Mimosa pudica, free radical scavenging, total phenolic content, writhing test, neuropharmacologica