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nan member of the bombesin family of neuropeptides. mammals including humans (Benya et al. 1995). The or. Thus, the portant to ds of GRPR (Moody et al. 2000, 2003), have been developed to Endocrine-Related Cancer (2008) 15 149–159breast, pancreatic, and colorectal cancers (Carroll et al.GRP mediates its effects by binding to a specific member of the seven transmembrane spanning G protein-coupled receptor super families (Battey et al. 1991). Research has demonstrated that GRP and GRP receptor (GRPR) are expressed aberrantly in various cancer cells such as small cell lung, prostate, gastric, inhibit the growth of various cancers. Other work