GRPR (Gastrin-Releasing Peptide Receptor)

Bombesin (BB) and gastrin-releasing peptide (GRP) bind with high affinity to the GRP-receptor (GRP-R) which regulates release of gastrointestinal hormones, smooth muscle contraction and proliferation of epithelial as well as cancer cells. The GRP-R is a G-protein coupled receptor (GPCR) which activates phospholipase C signaling pathways. The GRP-R is expressed in numerous cancers including breast, colon, lung and prostate cancer