3D difference detection is the task to verify whether the 3D geometry of a real object exactly corre-sponds to a 3D model of this object. Detecting differences between a real object and a 3D model of this object is for example required for industrial tasks such as prototyping, manufacturing and assembly control. State of the art approaches for 3D difference detection have the drawback that the difference detection is restricted to a single viewpoint from a static 3D position and that the differences cannot be detected in real time. This thesis introduces real-time 3D difference detection with a hand-held depth camera. In contrast to previous works, with the proposed approach, geometric differences can be detected in real time and from arbit...