<p>Levetiracetam (LEV), an antiepileptic drug (AED) with favorable pharmacokinetic profile, is increasingly being used in clinical practice, although information on its metabolism and disposition are still being generated. Therefore a simple, robust and fast liquid-liquid extraction (LLE) followed by high-performance liquid chromatography method is described that could be used for both pharmacokinetic and therapeutic drug monitoring (TDM) purposes. Moreover, recovery rates of LEV in plasma were compared among LLE, stir bar-sorptive extraction (SBSE), and solid-phase extraction (SPE). Solvent extraction with dichloromethane yielded a plasma residue free from usual interferences such as commonly co-prescribed AEDs, and recoveries around 90% (...
Objective: Assessment of the relevance between serum drug concentration to its therapeutic response ...
Methods based on HPLC technology are the most frequently adopted for monitoring blood levels of nove...
International audienceTherapeutic drug monitoring of antiepileptic drugs is widely practiced to achi...
none6An accurate and precise high-performance liquid chromatographic method using diode array detect...
A simple, fast and cost-effective method was developed and validated for the determination of leveti...
A simple liquid chromatography tandem mass spectrometry method was developed and validated according...
<div><p>A simple liquid chromatography tandem mass spectrometry method was developed and validated a...
Extraction of antiepileptic drugs (AEDs) can be carried out by different procedures which include: (...
The pharmacokinetic properties of a drug are the primary deter-minant of the extent and duration of ...
I Abstract { This article describes a rapid isocratic high-performance liquid chromatographic (HPLC)...
A simple, rapid, sensitive, and reproducible high-performance liquid chromatographic (HPLC) method f...
Levetiracetam is a new antiepileptic drug (AED) used for treating and preventing partial or generali...
A sensitive and reproducible stir bar-sorptive extraction and high-performance liquid chromatography...
A simple, rapid, sensitive, and reproducible high-performance liquid chromatographic (HPLC) method f...
The metabolic and the pharmacokinetics studies in the pharmaceutical industry at different developme...
Objective: Assessment of the relevance between serum drug concentration to its therapeutic response ...
Methods based on HPLC technology are the most frequently adopted for monitoring blood levels of nove...
International audienceTherapeutic drug monitoring of antiepileptic drugs is widely practiced to achi...
none6An accurate and precise high-performance liquid chromatographic method using diode array detect...
A simple, fast and cost-effective method was developed and validated for the determination of leveti...
A simple liquid chromatography tandem mass spectrometry method was developed and validated according...
<div><p>A simple liquid chromatography tandem mass spectrometry method was developed and validated a...
Extraction of antiepileptic drugs (AEDs) can be carried out by different procedures which include: (...
The pharmacokinetic properties of a drug are the primary deter-minant of the extent and duration of ...
I Abstract { This article describes a rapid isocratic high-performance liquid chromatographic (HPLC)...
A simple, rapid, sensitive, and reproducible high-performance liquid chromatographic (HPLC) method f...
Levetiracetam is a new antiepileptic drug (AED) used for treating and preventing partial or generali...
A sensitive and reproducible stir bar-sorptive extraction and high-performance liquid chromatography...
A simple, rapid, sensitive, and reproducible high-performance liquid chromatographic (HPLC) method f...
The metabolic and the pharmacokinetics studies in the pharmaceutical industry at different developme...
Objective: Assessment of the relevance between serum drug concentration to its therapeutic response ...
Methods based on HPLC technology are the most frequently adopted for monitoring blood levels of nove...
International audienceTherapeutic drug monitoring of antiepileptic drugs is widely practiced to achi...