Oxidized LDL Is Strictly Limited to Hyperthyroidism Irrespective of Fat Feeding in Female Sprague Dawley Rats

  • Sieglinde Zelzer
  • Harald Mangge
  • Sabine Pailer
  • Herwig Ainoedhofer
  • Petra Kieslinger
  • Tatjana Stojakovic
  • Hubert Scharnagl
  • Florian Prüller
  • Daniel Weghuber
  • Christian Datz
  • Johannes Haybaeck
  • Barbara Obermayer-Pietsch
  • Christian Trummer
  • Johanna Gostner
  • Hans-Jürgen Gruber
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Publication date
May 2015
Publisher
MDPI AG
ISSN
1422-0067
Journal
1422-0067
Citation count (estimate)
1

Abstract

Metabolic dysfunctions might play a crucial role in the pathophysiology of thyroid dysfunctions. This study aimed to investigate the impact of a controlled diet (normal versus high fat feeding) on hypothyroid and hyperthyroid Sprague Dawley rats. Female Sprague Dawley rats (n = 66) were grouped into normal diet (n = 30) and high-fat diet (n = 36) groups and subdivided into controls, hypothyroid and hyperthyroid groups, induced through propylthiouracil or triiodothyronine (T3) treatment, respectively. After 12 weeks of treatment metabolic parameters, such as oxidized LDL (oxLDL), malondialdehyde (MDA), 4-hydroxynonenal (HNE), the lipid profile, body weight and food intake parameters were analyzed. Successfully induced thyroid dysfunctions ...

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