Polyubiquitin is required for growth, development and pathogenicity in the rice blast fungus Magnaporthe oryzae.

  • Yeonyee Oh
  • William L Franck
  • Sang-Oh Han
  • Angela Shows
  • Emine Gokce
  • David C Muddiman
  • Ralph A Dean
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Publisher
Public Library of Science (PLoS)
Journal
issn:1932-6203

Abstract

Protein ubiquitination, which is highly selective, regulates many important biological processes including cellular differentiation and pathogenesis in eukaryotic cells. Here, we integrated pharmacological, molecular and proteomic approaches to explore the role of ubiquitination in Magnaporthe oryzae, the leading fungal disease of rice world-wide. Inhibition of ubiquitin-mediated proteolysis using the 26S proteasome inhibitor, Bortezomib, significantly attenuated conidia germination, appressorium formation and pathogenicity in M. oryzae. Gene expression analysis revealed that many genes associated with protein ubiquitination were developmentally regulated during conidia germination. Only a few, including a polyubiquitin encoding gene, MGG_0...

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