Complex carbohydrate utilization by the healthy human microbiome.

  • Brandi L Cantarel
  • Vincent Lombard
  • Bernard Henrissat
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Publisher
Public Library of Science (PLoS)
Journal
issn:1932-6203

Abstract

The various ecological habitats in the human body provide microbes a wide array of nutrient sources and survival challenges. Advances in technology such as DNA sequencing have allowed a deeper perspective into the molecular function of the human microbiota than has been achievable in the past. Here we aimed to examine the enzymes that cleave complex carbohydrates (CAZymes) in the human microbiome in order to determine (i) whether the CAZyme profiles of bacterial genomes are more similar within body sites or bacterial families and (ii) the sugar degradation and utilization capabilities of microbial communities inhabiting various human habitats. Upon examination of 493 bacterial references genomes from 12 human habitats, we found that sugar d...

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