Vitamin C Abrogates the Deleterious Effects of UVB Radiation on Cutaneous Immunity by a Mechanism That Does Not Depend on TNF-α

  • Nakamura, Toshiaki
  • Pinnell, Sheldon R.
  • Darr, Douglas
  • Kurimoto, Iwao
  • Itami, Satoshi
  • Yoshikawa, Kunihiko
  • Wayne Streilein, J.
Publication date
July 1997
Publisher
The Society for Investigative Dermatology, Inc. Published by Elsevier Inc.
ISSN
0022-202X
Citation count (estimate)
75

Abstract

Acute low-dose treatment of murine skin with ultra violet B (UVB) light impairs induction of contact hypersensitivity (CH) to dinitrofluorobenzene (DNFB) in certain inbred strains of mice (termed UVB-susceptible), but not in others (termed UVB-resistant), and promotes tolerance. These deleterious effects of ultraviolet radiation (UVR) are mediated in part by TNF-α, which is released from UVR-exposed epidermal and dermal cells. Because UVR damage to skin has also been ascribed in part to the generation of reactive oxygen intermediates (ROIs) such as super-oxide anion (O2−) hydrogen peroxide (H2O2), hydroxyl radical (OH−), and singlet oxygen (1O2), we investigated whether vitamin C (ascorbic acid), which can nullify ROIs, prevents the deleter...

Extracted data

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