A Landscape of Pharmacogenomic Interactions in Cancer

  • Iorio, Francesco
  • Knijnenburg, Theo A.
  • Vis, Daniel J.
  • Bignell, Graham R.
  • Menden, Michael P.
  • Schubert, Michael
  • Aben, Nanne
  • Gonçalves, Emanuel
  • Barthorpe, Syd
  • Lightfoot, Howard
  • Cokelaer, Thomas
  • Greninger, Patricia
  • van Dyk, Ewald
  • Chang, Han
  • de Silva, Heshani
  • Heyn, Holger
  • Deng, Xianming
  • Egan, Regina K.
  • Liu, Qingsong
  • Mironenko, Tatiana
  • Mitropoulos, Xeni
  • Richardson, Laura
  • Wang, Jinhua
  • Zhang, Tinghu
  • Moran, Sebastian
  • Sayols, Sergi
  • Soleimani, Maryam
  • Tamborero, David
  • Lopez-Bigas, Nuria
  • Ross-Macdonald, Petra
  • Esteller, Manel
  • Gray, Nathanael S.
  • Haber, Daniel A.
  • Stratton, Michael R.
  • Benes, Cyril H.
  • Wessels, Lodewyk F.A.
  • Saez-Rodriguez, Julio
  • McDermott, Ultan
  • Garnett, Mathew J.
Publication date
July 2016
Publisher
The Author(s). Published by Elsevier Inc.
ISSN
0092-8674
Citation count (estimate)
137

Abstract

SummarySystematic studies of cancer genomes have provided unprecedented insights into the molecular nature of cancer. Using this information to guide the development and application of therapies in the clinic is challenging. Here, we report how cancer-driven alterations identified in 11,289 tumors from 29 tissues (integrating somatic mutations, copy number alterations, DNA methylation, and gene expression) can be mapped onto 1,001 molecularly annotated human cancer cell lines and correlated with sensitivity to 265 drugs. We find that cell lines faithfully recapitulate oncogenic alterations identified in tumors, find that many of these associate with drug sensitivity/resistance, and highlight the importance of tissue lineage in mediating dru...

Extracted data

We use cookies to provide a better user experience.