A cross talk between the Estrogen Receptor (ESR1) and the Retinoblastoma (pRb) pathway has been demonstrated to influence the therapeutic response of breast cancer patients but the full mechanism remains poorly understood. Here we show that the N-terminal domain of pRb interacts with the CD domain of ESR1 to allow for the assembly of intermediate complex chaperone proteins HSP90 and p23. We demonstrated that a loss of pRb in human/mouse breast cells decreases the expression of the ESR1 protein through the proteasome pathway. Our work reveals a novel regulatory mechanism of ESR1 basal turnover and activity and an unanticipated relationship with the pRb tumor suppressor
Serine protease PRSS23 is a newly discovered protein that has been associated with tumor progression...
Progesterone receptor (PR) isoforms, PRA and PRB, act in a progesterone-independent and dependent ma...
Estrogens are required for the proliferation of hormone dependent breast cancer cells, making estrog...
A cross talk between the Estrogen Receptor (ESR1) and the Retinoblastoma (pRb) pathway has been demo...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
AbstractRecent studies reported that protein arginine methyltransferase 6 (PRMT6) enhances estrogen-...
Estrogens exhibit important biological functions and influence several pathological processes of hor...
Estrogens exhibit important biological functions and influence several pathological processes of hor...
The ovarian hormones estrogen and progesterone orchestrate postnatal mammary gland development and a...
Estrogen and progesterone are critically involved in the development of breast cancer and their effe...
The estrogen receptor-alpha (ER) plays a crucial role in normal breast development and is also linke...
Breast cancer prognosis and response to endocrine therapy strongly depends on the expression of the ...
Breast cancer prognosis and response to endocrine therapy strongly depends on the expression of the ...
Breast cancer is the second leading cause of cancer-related death in women, and approximately 70% of...
Progesterone receptor (PR) expression is employed as a biomarker of estrogen receptor-α (ERα) functi...
Serine protease PRSS23 is a newly discovered protein that has been associated with tumor progression...
Progesterone receptor (PR) isoforms, PRA and PRB, act in a progesterone-independent and dependent ma...
Estrogens are required for the proliferation of hormone dependent breast cancer cells, making estrog...
A cross talk between the Estrogen Receptor (ESR1) and the Retinoblastoma (pRb) pathway has been demo...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
AbstractRecent studies reported that protein arginine methyltransferase 6 (PRMT6) enhances estrogen-...
Estrogens exhibit important biological functions and influence several pathological processes of hor...
Estrogens exhibit important biological functions and influence several pathological processes of hor...
The ovarian hormones estrogen and progesterone orchestrate postnatal mammary gland development and a...
Estrogen and progesterone are critically involved in the development of breast cancer and their effe...
The estrogen receptor-alpha (ER) plays a crucial role in normal breast development and is also linke...
Breast cancer prognosis and response to endocrine therapy strongly depends on the expression of the ...
Breast cancer prognosis and response to endocrine therapy strongly depends on the expression of the ...
Breast cancer is the second leading cause of cancer-related death in women, and approximately 70% of...
Progesterone receptor (PR) expression is employed as a biomarker of estrogen receptor-α (ERα) functi...
Serine protease PRSS23 is a newly discovered protein that has been associated with tumor progression...
Progesterone receptor (PR) isoforms, PRA and PRB, act in a progesterone-independent and dependent ma...
Estrogens are required for the proliferation of hormone dependent breast cancer cells, making estrog...