User’s guide for TN/TNBC: Fortran routines for nonlinear optimization

injected into rats at i.p. doses of 1 to 10 mg/kg, prevented the lowering of brain serotonin by 4-cimloroamphetamine. The duration of 110140 action was very long, sig-imificaimt antagonism of 4-chloroampimetamine action being apparent still at 48 hours after a single dose of 10 mg/kg of 110140. The N,N-dimethyl tertiary amine derivative was as effective as 110140 itself in antagonizing serotonin depletion by 4-chioroam-phetamine, but other structurally related compounds had less activity or were inactive. Likewise, six tricyclic antidepressant drugs injected at 10 mg/kg i.p. did not antag-onize time action of 4-chloroamphetamine. Wimen injected into rats whose brain sero-tonin levels imad already been depleted by 3-hour pretreatment with 4-cimloroampheta-mine, 110140 terminated time action of 4-chloroamphetamine and permitted serotonin levels to return to normal. Lilly 110140 did not antagonize time depletion of brain serotonin or norepinepimrine by reserpine, which implies timat reserpine does not require the membrane pump for entry into the neuroim. The depletion of brain serotonin, but not Imorepinephrine, by a-etimyl-3-hydroxy-4-methylpimenethvlamine (1175/12) was blocked by 110140. In contrast to chlorimipramine, 110140 did not antagonize th