The traditional distinction between regulated and constitutive secretion may have contributed to the general belief that the latter is insensitive to extracellular modulatory signals. However, it now appears that signalling from membrane receptors can in fact modulate constitutive membrane traffic. In this article we discuss the molecular mechanisms, as well as the functional significance, of this modulation
In many instances, activation of cell surface receptors by extracellular signals causes modulation o...
The multicomponent modular nature of G protein-coupled receptor (GPCR) systems provides cells with n...
Transmembrane receptors monitor the extracellular environment and transmit information about chang...
Cells can change their function by rapidly modulating the levels of certain proteins at the plasma m...
Biochemical and morphometric approaches were combined to examine whether constitutive secretory tran...
Biochemical and morphometric approaches were combined to examine whether constitutive secretory tran...
The intracellular trafficking machinery contributes to the spatial and temporal control of signaling...
Cellular mechanisms of membrane traffic and signal transduction are deeply interconnected. The prese...
AbstractA variety of extracellular stimuli regulate cellular responses via membrane receptors. A wel...
Movements of a receptor in the plasma membrane and within the cell influence receptor function and p...
Signaling is regulated by endocytosis at multiple levels along endocytic routes. Endocytic control o...
A T cell-mediated immune response is initiated by the T cell receptor (TCR) interacting with peptide...
International audienceG-protein-coupled receptors (GPCRs) are dynamically regulated by various mecha...
Within any cellular signaling system membrane trafficking is a critical mechanism for cells to trans...
Regulated endocytic trafficking of receptors is emerging as an important way to control receptor act...
In many instances, activation of cell surface receptors by extracellular signals causes modulation o...
The multicomponent modular nature of G protein-coupled receptor (GPCR) systems provides cells with n...
Transmembrane receptors monitor the extracellular environment and transmit information about chang...
Cells can change their function by rapidly modulating the levels of certain proteins at the plasma m...
Biochemical and morphometric approaches were combined to examine whether constitutive secretory tran...
Biochemical and morphometric approaches were combined to examine whether constitutive secretory tran...
The intracellular trafficking machinery contributes to the spatial and temporal control of signaling...
Cellular mechanisms of membrane traffic and signal transduction are deeply interconnected. The prese...
AbstractA variety of extracellular stimuli regulate cellular responses via membrane receptors. A wel...
Movements of a receptor in the plasma membrane and within the cell influence receptor function and p...
Signaling is regulated by endocytosis at multiple levels along endocytic routes. Endocytic control o...
A T cell-mediated immune response is initiated by the T cell receptor (TCR) interacting with peptide...
International audienceG-protein-coupled receptors (GPCRs) are dynamically regulated by various mecha...
Within any cellular signaling system membrane trafficking is a critical mechanism for cells to trans...
Regulated endocytic trafficking of receptors is emerging as an important way to control receptor act...
In many instances, activation of cell surface receptors by extracellular signals causes modulation o...
The multicomponent modular nature of G protein-coupled receptor (GPCR) systems provides cells with n...
Transmembrane receptors monitor the extracellular environment and transmit information about chang...