In this chapter, we review the physiology of switchgrass from seed dormancy till the effects of water and nutrients stress on grown plants. These characteristics are presented and discussed mainly at the canopy and whole-plant level with emphasis on the agro-physiology of the species in view of the possible contribution of crop physiology to agricultural development. Switchgrass is noted for the variable degrees of seed dormancy regulated by endogenous and exogenous factors that determine the successful seedling establishment. Plant growth rates are determined by temperature while the reproductive phase is controlled mainly by photoperiod. There is also evidence that some physiological attributes, such as photosynthesis, transpiration, and ...