Combined toxic effects of nanoplastics and norfloxacin on mussel: Leveraging biochemical parameters and gut microbiota

  • Xu, Ran
  • Li, Li'ang
  • Zheng, Jiahui
  • Ji, Chenglong
  • Wu, Huifeng
  • Chen, Xiang
  • Chen, Yuchuan
  • Hu, Menghong
  • Xu, Elvis Genbo
  • Wang, Youji
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Publication date
July 2023

Abstract

Antibiotics and nanoplastics (NPs) are among the two most concerned and studied marine emerging contaminants in recent years. Given the large number of different types of antibiotics and NPs, there is a need to apply efficient tools to evaluate their combined toxic effects. Using the thick-shelled mussel (Mytilus coruscus) as a marine ecotoxicological model, we applied a battery of fast enzymatic activity assays and 16S rRNA sequencing to investigate the biochemical and gut microbial response of mussels exposed to antibiotic norfloxacin (NOR) and NPs (80 nm polystyrene beads) alone and in combination at environmentally relevant concentrations. After 15 days of exposure, NPs alone signifi-cantly inhibited superoxide dismutase (SOD) and amyla...

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