Is karyotyping and Y chromosome microdeletion study necessary in men candidate for ICSI?

  • Nowroozi, Mohammad Reza
  • Radkhah, Keivan
  • Ranjbaran, Alireza
  • Ghaffari, Saeed Reza
  • Gilani, Mohammad Ali Sedighi
  • Gourabi, Hamid
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Publication date
June 2010
Publisher
University of Toronto Medical Journal

Abstract

Background: The sperm count and function may be affected by karyotype abnormalities or microdeletion in Y chromosome. These genetic abnormalities can probably transmit to the children. Objective: In this study, we tried to determine the frequency of karyotype abnormalities and Y chromosome microdeletions in severe oligospermic or azoospermic men who fathered sons by ICSI. Materials and Methods: This study comprised of fathers who had at least a son with ICSI due to severe oligospermia or azoospermia. General examinations were done and blood sample were obtained for karyotype and Y chromosome studies. Results: The total of 60 fathers was evaluated along with their 70 sons. The mean duration of infertility was 8.7 years and the sons were 2.4 ...

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