Effects of Perfluoro Organic Compound Toxicity on Nematode Caenorhabditis elegans Fecundity

  • Tominaga, Nobuaki
  • Kohra, Shinya
  • Iguchi, Taisen
  • Arizono, Koji
Publication date
October 2004
Publisher
Pharmaceutical Society of Japan
ISSN
1344-9702
Journal
JOURNAL OF HEALTH SCIENCE
Citation count (estimate)
9

Abstract

Toxicity studies using the nematode Caenorhabditis elegans (C. elegans) as a model organism have shown that perfluoro organic compounds have sub-lethal toxicity at the 10 pM-100 nM range on multi-generation assays. We examined the acute lethal toxicity and multi-generational sublethal toxicity (fecundity and reproduction) of perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and salts of perfluoro-1-octansulfonic acid (PFOS) using 1.7% agar Nematode Growth Medium (NGM) plates. The fluorine compounds affected the fecundity of C. elegans at concentrations 105- to 108-fold lower than the median effective concentrations (EC50). In particular, worm abundance during the first generation did not differ significantly from controls, while ...

Extracted data

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