This thesis focuses on the application of the hierarchical Bayesian (HB) methodology to real data. The HB method is employed because of its many advantages in modeling, interpretation and in computation. It improves model fitting by pooling the data and borrowing strength from each other, and simplifies a complicated problem by breaking down a one-level structure into a multi-level hierarchical structure. The powerful Markov chain Monte Carlo technique allows us to apply the HB method to many complicated statistical problems that cannot be solved or would not be justified by the classical method. ^ We apply the HB method on three different examples, all of which are related to the longitudinal or time series data. ^ In the first example...