Comparison Between Glycopyrrolate And Atropine as a Premedicant on Hemodynamic Stability in Pediatric Anesthesia

Comparison Between Glycopyrrolate And Atropine as a Premedicant on Hemodynamic Stability in Pediatric Anesthesia Dr. Iyad Abbas1,Dr. Ahmed M.H2,Dr. Taghreed Abbas Salman3* Abstract Background: Most (82%) arrests in pediatric anesthesia was occurred during induction of anaesthesia;bradycardia, hypotension, and a low spo2 were frequent preceding events. The most common mechanismof cardiac arrest was judged to be medication related.Cardiovascular depression from halothane alone or in combination with other drugs, was believed to be responsible in 66% of all medication related arrests. Aim of study: To compare between glycopyrrolate and atropine as a premedicant on haemodynamic stability in paediatric anaesthesia. Patient and method: An interventional clinical trial was carried out in Pedeatric Surgery theatres of Baghdad Teaching Hospital.40 pediatric patients divided in two groups A and B.Group A:20 patients, Who received glycopyrrolate 0.004mg/kg as premedication.Group B: 20 patients, who received atropine 0.02mg/kg as premedication. Anesthesia was induced with an analgesic dose of ketamine 0.5mg/kg, induction dose of thiopental up to 3-5 mg/kg and tracheal intubation (with size according to the age of the patient) was facilitated with 0.5 mg/Kg of atracurium. Anesthesia was maintained with halothane 0.6-1.0% in 100% oxygen and i.v fluid. Neuromuscular blockade was maintained with incremental doses of 0.1mg/kg atracurium. Reversal dose giving at the end of the operation. Monitoring O2 saturation, NIBP,ECG and pulse rate. Result: By using the SPSS V.20/IBM using the t-student test and the chi square it was found there is no significant differences between the Atropine group and glycopyrolate group in age, weight, blood pressure. Basal pulse rate and pulse rate at 10 minutes and above were the p-values were above 0.05.There are significant differences between glycopyrolate group and atropine groups at 1 minutes after test dose, after intubation, 5minutes after and 10 minutes after. Conclusion: Patients who received Glycopyrrolate were more haemodynamic stable than those who received atropine regarding change in pulserate in the first 15 minutesCitation: Abbas I,Ahmed M.H, Salman T.AComparison Between Glycopyrrolate And Atropine as a Premedicant on Hemodynamic Stability in Pediatric Anesthesia. Academic Journal of Medical Sciences, 2022, 8(3):183-53, doi.org. 10.5281/zenodo.693080