Molecular architecture of nucleosome remodeling and deacetylase sub-complexes by integrative structure determination
- Arvindekar, Shreyas
- Jackman, Matthew J.
- Low, Jason K.K.
- Landsberg, Michael J.
- Mackay, Joel P.
- Viswanath, Shruthi
View in ORKG Publication date
May 2022
DOIAbstract
Drawing on information from SEC-MALLS, DIA-MS, XLMS, negative-stain EM, X-ray crystallography, NMR spectroscopy, secondary structure predictions, and homology models, we applied Bayesian integrative structure determination to investigate the molecular architecture of three NuRD sub-complexes: MTA1-HDAC1-RBBP4 (MHR), MTA1N-HDAC1-MBD3GATAD2CC (MHM), and MTA1-HDAC1-RBBP4-MBD3-GATAD2A (NuDe). The present dataset pertains to the results of this study