Evaluation of T helper17 as skeletal homeostasis factor in peripheral blood mononuclear cells and T helper cells of end-stage renal disease cases with impaired parathyroid hormone

  • Motavalli, R.
  • Soltani-Zangbar, M.S.
  • Fereydoonzadeh, K.
  • Hajivalili, M.
  • Heris, J.A.
  • Kahroba, H.
  • Niknafs, B.
  • Khiavi, F.M.
  • Dolati, S.
  • Sadeghi, M.
  • Yousefi, M.
  • Etemadi, J.
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Publication date
May 2023

Abstract

Background Chronic renal failure is mainly connected with high and low parathyroid hormone (PTH) levels and immunological impairments. The present study aimed to evaluate T helper 17 (Th17) cells as a crucial modulator of the immune system and skeletal homeostasis in hemodialysis patients with impaired intact PTH (iPTH).Methods In this research, blood samples were taken from ESRD patients with high (> 300 pg/mL), normal (150-300 pg/mL), and low (< 150 pg/mL) serum intact parathyroid hormone (iPTH( levels (n = 30 in each group). The frequency of Th17 (CD4(+) IL17(+)) cells was evaluated by flow cytometry in each group. The expression levels of Th17 cell-related master transcription factors, cytokines in peripheral blood mononuclear cel...

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