Epidemiology and burden of systemic lupus erythematosus in a Southern European population:data from the community-based lupus registry of Crete, Greece

  • Gergianaki, Irini
  • Fanouriakis, Antonis
  • Repa, Argyro
  • Tzanakakis, Michalis
  • Adamichou, Christina
  • Pompieri, Alexandra
  • Spirou, Giorgis
  • Bertsias, Antonios
  • Kabouraki, Eleni
  • Tzanakis, Ioannis
  • Chatzi, Leda
  • Sidiropoulos, Prodromos
  • Boumpas, Dimitrios T.
  • Bertsias, George K.
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Publication date
December 2017

Abstract

Objectives Several population-based studies on systemic lupus erythematosus (SLE) have been reported, yet community-based, individual-case validated, comprehensive reports are missing. We studied the SLE epidemiology and burden on the island of Crete during 1999-2013.Methods Multisource case-finding included patients >= 15 years old. Cases were ascertained by the ACR 1997, SLICC 2012 criteria and rheumatologist diagnosis, and validated through synthesis of medical charts, administrative and patient-generated data.Results Overall age-adjusted/sex-adjusted incidence was 7.4 (95% CI 6.8 to 7.9) per 100 000 persons/year, with stabilising trends in women but increasing in men, and average (+/- SD) age of diagnosis at 43 (+/- 15) years. Adjust...

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