Pectins that Structurally Differ in the Distribution of Methyl-Esters Attenuate Citrobacter rodentium-Induced Colitis

  • Beukema, Martin
  • Akkerman, Renate
  • Jermendi, Éva
  • Koster, Taco
  • Laskewitz, Anne
  • Kong, Chunli
  • Schols, Henk A
  • Faas, Marijke M
  • de Vos, Paul
Publication date
October 2021
Language
English

Abstract

SCOPE: Pectins have anti-inflammatory properties on intestinal immunity through direct interactions on Toll-like receptors (TLRs) in the small intestine or via stimulating microbiota-dependent effects in the large intestine. Both the degree of methyl-esterification (DM) and the distribution of methyl-esters (degree of blockiness; DB) of pectins contribute to this influence on immunity but whether and how the DB impacts immunity through microbiota-dependent effects in the large intestine is unknown. Therefore, we tested pectins that structurally differ in DB in a mouse model with Citrobacter rodentium-induced colitis and studied the impact on the intestinal microbiota composition and associated attenuation of inflammation.METHODS AND RESULTS...

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