(111)Indium-trastuzumab visualises myocardial human epidermal growth factor receptor 2 expression shortly after anthracycline treatment but not during heart failure:A clue to uncover the mechanisms of trastuzumab-related cardiotoxicity

  • de Korte, M. A.
  • de Vries, E. G. E.
  • Lub-de Hooge, M. N.
  • Jager, P. L.
  • Gietema, J. A.
  • van der Graaf, W. T. A.
  • Sluiter, W. J.
  • van Veldhuisen, D. J.
  • Suter, T. M.
  • Sleiffer, D. T.
  • Perik, P. J.
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Publication date
September 2007

Abstract

Aim: Trastuzumab can induce cardiotoxicity, particularly when combined with anthracyclines. Myocardial human epidermal growth factor receptor 2 (HER2) expression may be transiently upregulated by a compensatory mechanism following cardiac stress. In-111 DTPA-trastuzumab, scintigraphy can detect HER2 positive tumour lesions, however previously, we found myocardial uptake in only 1 of the 15 anthracycline-pre-treated patients with a median of 11 months after the last anthracycline administration. To evaluate whether myocardial HER2 expression is upregulated by anthracycline-induced cardiac stress or in case of heart failure by chronic pressure or volume overload, we performed In-111-DTPA-trastuzumab scans in patients shortly after anthracycli...

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