Bridging intergrator-1, BIN1, functions in membrane recycling, cytoskeleton regulation, DNA repair, and cell proliferation. As a tumor suppressor, BIN1 binds to c-MYC to inhibit S-phase gene transcription aand the N-terminus sequesters PARP, stopping DNA repair, and promoting apoptosis. Decreases in overall levels if BIN1 correlate with poor cancer prognosis. Additionally, BIN1 message can be alternatively spliced, creating isoforms lacking the myc-binding domain. This study was designed to investigate a potential role of BIN1 in viral tumorigenesis by comparing the accumulated levels and isoforms in immortalized human diploid fibroblasts and their simian virus 40 transformed counterparts. RTPCR, revealed several processed transcripts and i...
Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene as the most i...
Cell motility, adhesion and phagocytosis are controlled by actin and membrane remodelling processes....
<div><p>Cell motility, adhesion and phagocytosis are controlled by actin and membrane remodelling pr...
The BIN1 gene product, Amphiphysin 2, has been shown to act as a tumor suppressor (Prokic, et al., 2...
Bin1 is a ubiquitous nucleocytoplasmic adaptor protein that was identified through its ability to in...
Bin1 is a Myc-interacting protein with features of a tumor suppressor. The high level of Bin1 expres...
It has been shown that bridging integrator 1 (BIN1) can interact with c-myelocytomatosis (c-Myc) onc...
Cancer is most commonly thought of as the result of accumulation of cellular DNA mutations that inhi...
Cutaneous T-cell lymphomas (CTCLs) represent a group of lymphoproliferative disorders characterized ...
The tumor suppressor bridging integrator 1 (BIN1) is a corepressor of the transcription factor E2F1 ...
Bin1 is a novel protein that specifically binds Myc and inhibits, at least in part, Myc transactivat...
The E2F1 transcription factor was originally identified as a cellular target that is induced by the ...
The pro-apoptotic tumor suppressor BIN1 inhibits the activities of the neoplastic transcription fact...
Rhabdomyosarcoma (RMS) is the most common pediatric soft-tissue sarcoma. Although the precise cell t...
The cellular membrane is a highly heterogeneous and dynamic system whose compositions and morphologi...
Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene as the most i...
Cell motility, adhesion and phagocytosis are controlled by actin and membrane remodelling processes....
<div><p>Cell motility, adhesion and phagocytosis are controlled by actin and membrane remodelling pr...
The BIN1 gene product, Amphiphysin 2, has been shown to act as a tumor suppressor (Prokic, et al., 2...
Bin1 is a ubiquitous nucleocytoplasmic adaptor protein that was identified through its ability to in...
Bin1 is a Myc-interacting protein with features of a tumor suppressor. The high level of Bin1 expres...
It has been shown that bridging integrator 1 (BIN1) can interact with c-myelocytomatosis (c-Myc) onc...
Cancer is most commonly thought of as the result of accumulation of cellular DNA mutations that inhi...
Cutaneous T-cell lymphomas (CTCLs) represent a group of lymphoproliferative disorders characterized ...
The tumor suppressor bridging integrator 1 (BIN1) is a corepressor of the transcription factor E2F1 ...
Bin1 is a novel protein that specifically binds Myc and inhibits, at least in part, Myc transactivat...
The E2F1 transcription factor was originally identified as a cellular target that is induced by the ...
The pro-apoptotic tumor suppressor BIN1 inhibits the activities of the neoplastic transcription fact...
Rhabdomyosarcoma (RMS) is the most common pediatric soft-tissue sarcoma. Although the precise cell t...
The cellular membrane is a highly heterogeneous and dynamic system whose compositions and morphologi...
Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene as the most i...
Cell motility, adhesion and phagocytosis are controlled by actin and membrane remodelling processes....
<div><p>Cell motility, adhesion and phagocytosis are controlled by actin and membrane remodelling pr...