Introduction: odontogenic keratocyst has histopathological significance, with interesting biological and pathological behavior. Its high recurrence rate and great capacity to destroy areas of medullary bone make it one of the most aggressive cysts.Objective: to characterize the diagnosis and update treatment of odontogénico keratocyst.Method: an updated bibliographic review on the subject was carried out in the period between February and April 2021. The search used textbooks and the resources available on the Infomed network, specifically: PubMed, SciELO and Ebesco, through databases: Medline, Academic Search Premier, MedicLatina; in addition to Cudmed, Lilacs and Scopus. From a total of 56 articles related to the topic, 24 were selected a...