Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy

  • Correia, Ana Luísa
  • Guimaraes, Joao C.
  • Auf der Maur, Priska
  • De Silva, Duvini
  • Trefny, Marcel P.
  • Okamoto, Ryoko
  • Bruno, Sandro
  • Schmidt, Alexander
  • Mertz, Kirsten
  • Volkmann, Katrin
  • Terracciano, Luigi
  • Zippelius, Alfred
  • Vetter, Marcus
  • Kurzeder, Christian
  • Weber, Walter Paul
  • Bentires-Alj, Mohamed
Publication date
January 2021
Publisher
Springer Science and Business Media LLC
Language
English

Abstract

The persistence of undetectable disseminated tumour cells (DTCs) after primary tumour resection poses a major challenge to effective cancer treatment; 1-3; . These enduring dormant DTCs are seeds of future metastases, and the mechanisms that switch them from dormancy to outgrowth require definition. Because cancer dormancy provides a unique therapeutic window for preventing metastatic disease, a comprehensive understanding of the distribution, composition and dynamics of reservoirs of dormant DTCs is imperative. Here we show that different tissue-specific microenvironments restrain or allow the progression of breast cancer in the liver-a frequent site of metastasis; 4; that is often associated with a poor prognosis; 5; . Using mouse models,...

Extracted data

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