Intimal calcification and vascular stiffening are predominant features of end-stage atherosclerosis. However, their role in atherosclerotic plaque instability and how the extent and spatial distribution of calcification influence plaque biology remain unclear. We recently showed that extensive macro calcification can be a stabilizing feature of late-stage human lesions, associated with a reacquisition of more differentiated properties of plaque smooth muscle cells (SMCs) and extracellular matrix (ECM) remodeling. Here, we hypothesized that biomechanical forces related to macro-calcification within plaques influence SMC phenotype and contribute to plaque stabilization. We generated a finite element modeling (FEM) pipeline to assess plaque ti...
Rupture of the cap of an atherosclerotic plaque can lead to thrombotic cardiovascular events. It has...
Clinical evidence links arterial calcification and cardiovascular risk. Finite-element modelling of ...
Vascular calcification is associated with poor cardiovascular outcome. Histochemical analysis of cal...
Intimal calcification and vascular stiffening are predominant features of end-stage atherosclerosis....
Calcification (CALC) is a predominant feature of late-stage cardiovascular disease (CVD) but respons...
Abstract Background This study characterizes the distribution and components of plaque structure by ...
Vascular calcification, a complex component that forms in the walls of arteries as part of advanced...
Background: Calcification, a key feature of advanced human atherosclerosis, is positively associated...
Large calcifications often develop in advanced atherosclerotic plaques. Prior computational studies...
Acute cerebral ischemic events and thrombosis are associated with the rupture/erosion of carotid ath...
Background: The impact of calcification on the carotid atherosclerotic plaque vulnerability remains ...
Rupture of the cap of an atherosclerotic plaque can lead to thrombotic cardiovascular events. It has...
BACKGROUND: Stretch is a mechanical parameter, which has been proposed previously to affect the biol...
Arterial remodeling refers to the structural and functional changes of the vessel wall that occur in...
Objective: Atherosclerotic plaque rupture in carotid arteries is a major source of cerebrovascular e...
Rupture of the cap of an atherosclerotic plaque can lead to thrombotic cardiovascular events. It has...
Clinical evidence links arterial calcification and cardiovascular risk. Finite-element modelling of ...
Vascular calcification is associated with poor cardiovascular outcome. Histochemical analysis of cal...
Intimal calcification and vascular stiffening are predominant features of end-stage atherosclerosis....
Calcification (CALC) is a predominant feature of late-stage cardiovascular disease (CVD) but respons...
Abstract Background This study characterizes the distribution and components of plaque structure by ...
Vascular calcification, a complex component that forms in the walls of arteries as part of advanced...
Background: Calcification, a key feature of advanced human atherosclerosis, is positively associated...
Large calcifications often develop in advanced atherosclerotic plaques. Prior computational studies...
Acute cerebral ischemic events and thrombosis are associated with the rupture/erosion of carotid ath...
Background: The impact of calcification on the carotid atherosclerotic plaque vulnerability remains ...
Rupture of the cap of an atherosclerotic plaque can lead to thrombotic cardiovascular events. It has...
BACKGROUND: Stretch is a mechanical parameter, which has been proposed previously to affect the biol...
Arterial remodeling refers to the structural and functional changes of the vessel wall that occur in...
Objective: Atherosclerotic plaque rupture in carotid arteries is a major source of cerebrovascular e...
Rupture of the cap of an atherosclerotic plaque can lead to thrombotic cardiovascular events. It has...
Clinical evidence links arterial calcification and cardiovascular risk. Finite-element modelling of ...
Vascular calcification is associated with poor cardiovascular outcome. Histochemical analysis of cal...