Aberrant expression of microRNAs (miRNAs) has been associated with clinical outcome in patients with chronic lymphocytic leukemia (CLL). To identify a powerful and easily assessable miRNA bio-marker of prognosis and survival, we performed quantitative reverse-transcription polymerase chain reaction (qRT-PCR) profiling in 104 CLL patients with a well-defined chromosome 17p status, and we validated our findings with miRNA microarray data from an independent cohort of 80 patients. We found that miR-15a, miR-21, miR-34a, miR-155, and miR-181b were differentially expressed between CLLs with chromosome 17p deletion and CLLs with normal 17p and normal karyotype, and that miR-181b was down-regulated in therapy-refractory cases. miR-21 expression le...
PURPOSE: Despite its indolent nature, chronic lymphocytic leukemia (CLL) remains an incurable diseas...
Purpose: Despite its indolent nature, chronic lymphocytic leukemia (CLL) remains an incurable diseas...
Chronic lymphocytic leukemia (CLL) is thought to be a disease of resting lymphocytes. However, recen...
MicroRNAs (miRNAs) are a novel class of small noncoding RNAs that modulate the expression of genes a...
Chromosomal abnormalities, immunoglobulin heavy chain variable-region (IGHV) gene mutation status, a...
MicroRNAs play a crucial role in chronic lymphocytic leukemia. We investigated whether microRNAs can...
Aberrant expression of microRNAs has been recently associated with chronic lymphocytic leukemia (CLL...
BACKGROUND: MicroRNA expression profiles can be used to distinguish normal B cells from malignant B ...
MicroRNAs play a crucial role in chronic lymphocytic leukemia. We investigated whether microRNAs can...
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia and is characterized by chromos...
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia and is characterized by chromos...
MicroRNA-155-5p (miR-155-5p) is a proinflammatory, oncogenic miRNA, involved in various physiologica...
MicroRNAs (miRNAs) are a novel class of small noncoding RNA molecules that regulate gene expression ...
Chronic lymphocytic leukemia (CLL), the most frequent leukemia in adults in the Western world, is ch...
During many years, chemo-immunotherapy fludarabine-cyclophosphamide-rituximab (FCR) was the gold sta...
PURPOSE: Despite its indolent nature, chronic lymphocytic leukemia (CLL) remains an incurable diseas...
Purpose: Despite its indolent nature, chronic lymphocytic leukemia (CLL) remains an incurable diseas...
Chronic lymphocytic leukemia (CLL) is thought to be a disease of resting lymphocytes. However, recen...
MicroRNAs (miRNAs) are a novel class of small noncoding RNAs that modulate the expression of genes a...
Chromosomal abnormalities, immunoglobulin heavy chain variable-region (IGHV) gene mutation status, a...
MicroRNAs play a crucial role in chronic lymphocytic leukemia. We investigated whether microRNAs can...
Aberrant expression of microRNAs has been recently associated with chronic lymphocytic leukemia (CLL...
BACKGROUND: MicroRNA expression profiles can be used to distinguish normal B cells from malignant B ...
MicroRNAs play a crucial role in chronic lymphocytic leukemia. We investigated whether microRNAs can...
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia and is characterized by chromos...
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia and is characterized by chromos...
MicroRNA-155-5p (miR-155-5p) is a proinflammatory, oncogenic miRNA, involved in various physiologica...
MicroRNAs (miRNAs) are a novel class of small noncoding RNA molecules that regulate gene expression ...
Chronic lymphocytic leukemia (CLL), the most frequent leukemia in adults in the Western world, is ch...
During many years, chemo-immunotherapy fludarabine-cyclophosphamide-rituximab (FCR) was the gold sta...
PURPOSE: Despite its indolent nature, chronic lymphocytic leukemia (CLL) remains an incurable diseas...
Purpose: Despite its indolent nature, chronic lymphocytic leukemia (CLL) remains an incurable diseas...
Chronic lymphocytic leukemia (CLL) is thought to be a disease of resting lymphocytes. However, recen...