In vivo evidence for a role of adipose tissue SR-BI in the nutritional and hormonal regulation of adiposity and cholesterol homeostasis.

  • Yvan-Charvet, L.
  • Bobard, A.
  • Bossard, P.
  • Massiéra, F.
  • Rousset, X.
  • Ailhaud, G.
  • Teboul, M.
  • Ferré, P.
  • Dagher, G.
  • Quignard-Boulangé, A.
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Publication date
June 2007
Publisher
American Heart Association

Abstract

International audienceOBJECTIVES: This study examines the role of insulin and angiotensin II in high-density lipoprotein (HDL) metabolism by focusing on the regulation and function of scavenger receptor type-BI (SR-BI) in adipose tissue. METHODS AND RESULTS: Insulin or angiotensin II injection in wild-type mice induced a decrease in circulating HDL and it was associated with the translocation of SR-BI from intracellular sites to the plasma membrane of adipose tissue. Refeeding upregulated adipose HDL selective cholesteryl esters uptake and SR-BI proteins through transcriptional and posttranscriptional mechanisms. This occurred along with a decrease in serum HDL and an increase in adipose cholesterol content. Similar results were obtained wi...

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