Association Between Low-Dose Aspirin and Uric Acid in the Elderly: An Observational Retrospective Cross-Sectional Study

Jia-Run Li, Yan Fan, Mei-Lin Liu Department of Geriatrics, Peking University First Hospital, Beijing, 100034, People’s Republic of ChinaCorrespondence: Mei-Lin Liu Tel +86 13910251863Email liumeilin@hotmail.comPurpose: Uric acid is an independent factor for arteriosclerotic cardiovascular disease (ASCVD). Although aspirin is one of the most widely used agent in patients with ASCVD, there were only a few studies focusing on the effects of low-dose aspirin on uric acid metabolism with controversial results. The present study aimed to investigate an association between low-dose aspirin treatment for more than one month and serum uric acid (SUA) with its urinary excretion in elderly patients.Patients and Methods: This paper presents an observational retrospective cross-sectional study to determine the association between continuous daily taking low-dose aspirin (50– 100mg) for more than one month and SUA with fraction excretion of uric acid (FEUA) in elderly patients. A total of 506 inpatients equal or over 60 in Department of Geriatrics of Peking University First Hospital were enrolled from 2017 to 2020. About 41.9% of them were taking aspirin for more than one month, while others were not taking this medicine. The correlation between aspirin use and SUA or FEUA was analyzed, and group-comparison was performed in different dosage groups of aspirin.Results: After correcting confounding factors, there is no remarkable correlation between taking low-dose aspirin and SUA or FEUA, but a decreasing trend (coefficients=− 4.946) of SUA in hyperuricemia patients with low-dose aspirin was observed despite no obvious difference (P=0.534). Whether SUA or FEUA has no significant difference between 50mg/d and 100mg/d aspirin subjects.Conclusion: SUA and urinary uric acid excretion are not associated with using of 50– 100mg/d aspirin for more than one month in elderly patients with ASCVD or at risk.Keywords: aspirin, uric acid, excretion, arteriosclerotic cardiovascular disease, elderl