Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus: Data from the UK Juvenile-onset systemic lupus erythematosus cohort study

  • Giani, T
  • Smith, E
  • Al Abadi, E
  • Armon, K
  • Bailey, K
  • Ciurtin, C
  • Davidson, J
  • Gardner-Medwin, J
  • Haslam, K
  • Hawley, D
  • Beresford, M
  • Hedrich, C
Publication date
October 2021
Publisher
Academy of Traumatology
Language
English

Abstract

INTRODUCTION: Juvenile-onset systemic lupus erythematosus (JSLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Neuropsychiatric (NP) involvement is a severe complication, encompassing a heterogeneous range of neurological and psychiatric manifestations. METHODS: Demographic, clinical, and laboratory features of NP-SLE were assessed in participants of the UK JSLE Cohort Study, and compared to patients in the same cohort without NP manifestations. RESULTS: A total of 428 JSLE patients were included in this study, 25% of which exhibited NP features, half of them at first visit. Most common neurological symptoms among NP-JSLE patients included headaches (78.5%), mood disorders (48.6%), cognitive impairment ...

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