Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro
- Share, Andrew I.
- Patel, Khushali
- Nativi, Cristina
- Cho, Eun-Jeong
- Francesconi, Oscar
- Busschaert, Nathalie
- Gale, Philip A.
- Roelens, Stefano
- Sessler, Jonathan L.
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Royal Society of Chemistry (RSC)Abstract
A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl– transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro. The best transporters proved effective against the methicillin-resistant Staphylococcus aureus (MRSA) strains, Mu50 and HP1173. Tris-thiourea tren-based chloride transporters were also shown to inhibit the growth of S. aureus. in vitro.<br/