THE INTERACTION OF THE NEW HALF-SYNTHETIC DERIVATIVES OF THE ANTRACYCLINE ANTIBIOTICS WITH SENSITIVE AND RESISTANT TUMOR CELLS IN VITRO

The object of investigation: the new half-syntetic derivatives of the antracycline antibiotics doxorubicine, daunorubicine and carminomycine, the cells of the solid tumors of the man and leukosis of mice. For the first time, with use of the panel of lines of the man's and mouse's tumor cells, sensitive and stable to the antracyclines, the cytotoxic activity of the 15 new derivatives of the antracycline antibiotics, has been studied. Some possible mechanisms of overcoming the MDR tumor cells by the new 14-0-hemiadipinate of doxorubicine has been established. The new preparations and the new system of selection (the experimental stage) have been introduced in practiceAvailable from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio