Background The C allele of the interferon-induced transmembrane protein-3 (IFITM3) SNP rs12252, a common allele in South East Asia and China, is strongly associated with severe influenza infection. However, despite the high occurrence of rs12252-CC genotype in Chinese population (~25%), severe influenza infection is rare. The aim of study is to determine whether rs12252-CC individuals have pre-existing antibody responses to previous seasonal influenza infections. Cohort and Method A total 99 young healthy volunteers (18–20 years) were recruited and received an influenza seasonal Vaccination [A/Switzerland/9715293/2013(H3N2), A/California/7/2009 (pdm09H1N1) and B/Jeep/3073/2013-like virus (Flu-B)]. Plasma and gDNA was isolated from each volu...
[[abstract]]A novel pandemic influenza H1N1 (pH1N1) virus spread rapidly across the world in 2009. D...
The IFITM3 protein is a prominent restriction factor of influenza virus that has been shown to antag...
AbstractTo assess gene signatures related to humoral response among healthy older subjects following...
Background The C allele of the interferon-induced transmembrane protein-3 (IFITM3) SNP rs12252, a co...
Background: Interferon Inducible Transmembrane 3 (IFITM3) is a key factor in interferon pathway and ...
The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasin...
The pandemic influenza A (H1N1) pdm09 virus, avian influenza A (H5N1) virus, and influenza A (H7N9) ...
Interferon-inducible transmembrane protein (IFITM3) inhibits the entry of viruses to the host cell, ...
Background The pandemic influenza A (H1N1) pdm09 virus, avian influenza A (H5N1) virus, and influen-...
Pandemic influenza viruses often cause severe disease in middle-aged adults without preexistent co-m...
The role of host genetics in influenza infection is unclear despite decades of interest. Confounding...
<div><p>A key observation about the human immune response to repeated exposure to influenza A is tha...
The 2009 H1N1 influenza pandemic showed the speed with which a novel respiratory virus can spread an...
A major unanswered question in the current global COVID-19 outbreak is why a small minority of infec...
Recent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs1...
[[abstract]]A novel pandemic influenza H1N1 (pH1N1) virus spread rapidly across the world in 2009. D...
The IFITM3 protein is a prominent restriction factor of influenza virus that has been shown to antag...
AbstractTo assess gene signatures related to humoral response among healthy older subjects following...
Background The C allele of the interferon-induced transmembrane protein-3 (IFITM3) SNP rs12252, a co...
Background: Interferon Inducible Transmembrane 3 (IFITM3) is a key factor in interferon pathway and ...
The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasin...
The pandemic influenza A (H1N1) pdm09 virus, avian influenza A (H5N1) virus, and influenza A (H7N9) ...
Interferon-inducible transmembrane protein (IFITM3) inhibits the entry of viruses to the host cell, ...
Background The pandemic influenza A (H1N1) pdm09 virus, avian influenza A (H5N1) virus, and influen-...
Pandemic influenza viruses often cause severe disease in middle-aged adults without preexistent co-m...
The role of host genetics in influenza infection is unclear despite decades of interest. Confounding...
<div><p>A key observation about the human immune response to repeated exposure to influenza A is tha...
The 2009 H1N1 influenza pandemic showed the speed with which a novel respiratory virus can spread an...
A major unanswered question in the current global COVID-19 outbreak is why a small minority of infec...
Recent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs1...
[[abstract]]A novel pandemic influenza H1N1 (pH1N1) virus spread rapidly across the world in 2009. D...
The IFITM3 protein is a prominent restriction factor of influenza virus that has been shown to antag...
AbstractTo assess gene signatures related to humoral response among healthy older subjects following...