High level antibody response to pandemic influenza H1N1/09 virus is associated with interferon-induced transmembrane protein-3 rs12252-CC in young adults

  • Qin, L
  • Wang, D
  • Li, D
  • Zhao, Y
  • Peng, Y
  • Wellington, D
  • Dai, Y
  • Sun, H
  • Sun, J
  • Liu, G
  • McMichael, A
  • Dong, T
  • Zhang, Y
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Publication date
January 2018
Publisher
Frontiers Media SA

Abstract

Background The C allele of the interferon-induced transmembrane protein-3 (IFITM3) SNP rs12252, a common allele in South East Asia and China, is strongly associated with severe influenza infection. However, despite the high occurrence of rs12252-CC genotype in Chinese population (~25%), severe influenza infection is rare. The aim of study is to determine whether rs12252-CC individuals have pre-existing antibody responses to previous seasonal influenza infections. Cohort and Method A total 99 young healthy volunteers (18–20 years) were recruited and received an influenza seasonal Vaccination [A/Switzerland/9715293/2013(H3N2), A/California/7/2009 (pdm09H1N1) and B/Jeep/3073/2013-like virus (Flu-B)]. Plasma and gDNA was isolated from each volu...

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