Association of Genome-Wide Variation With the Risk of Incident Heart Failure in Adults of European and African Ancestry: A Prospective Meta-Analysis From the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium
- Smith, Nicholas L.
- Felix, Janine F.
- Morrison, Alanna C.
- Demissie, Serkalem
- Glazer, Nicole L.
- Loehr, Laura R.
- Cupples, L. Adrienne
- Dehghan, Abbas
- Lumley, Thomas
- Rosamond, Wayne D.
- Lieb, Wolfgang
- Rivadeneira, Fernando
- Bis, Joshua C.
- Folsom, Aaron R.
- Benjamin, Emelia
- Aulchenko, Yurii S.
- Haritunians, Talin
- Couper, David
- Murabito, Joanne
- Wang, Ying A.
- Stricker, Bruno H.
- Gottdiener, John S.
- Chang, Patricia P.
- Wang, Thomas J.
- Rice, Kenneth M.
- Hofman, Albert
- Heckbert, Susan R.
- Fox, Ervin R.
- O'Donnell, Christopher J.
- Uitterlinden, Andre G.
- Rotter, Jerome I.
- Willerson, James T.
- Levy, Daniel
- Van Duijn, Cornelia M.
- Psaty, Bruce M.
- Witteman, Jacqueline C.M.
- Boerwinkle, Eric
- Vasan, Ramachandran S.
View in ORKG Publication date
January 2010
DOIAbstract
Although genetic factors contribute to the onset of heart failure (HF), no large-scale genome-wide investigation of HF risk has been published to date. We investigated the association of 2,478,304 single nucleotide polymorphisms (SNPs) with incident HF by meta-analyzing data from 4 community-based prospective cohorts: the Atherosclerosis Risk in Communities Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study