[[alternative]]Explore the correlation between serum level of vitamin D and atherosclerosis in physical examination individual of own payment

[[abstract]]背景：心血管疾病 (Cardiovascular disease, CVD) 已多年蟬聯全球死因第一名，且流行病學研究已證實維生素D缺乏為一個獨立的心血管疾病風險因子，但是針對血中維生素D狀態和心血管疾病的前驅變化動脈粥狀硬化相關性仍未有一致的結論，並且台灣血中維生素D狀態和動脈粥狀硬化的研究有限。目的：本研究旨在探討2018年1月1日至2018年12月31日間自費健康檢查民眾血中維生素D狀態與動脈粥狀硬化的相關性。方法：本研究為橫斷性研究，使用北市某健康檢查中心次級資料庫資料進行研究，572位頸動脈超音波檢查及212位冠狀動脈電腦攝影檢查者，評估動脈粥狀硬化狀態。維生素D狀態分為正常、不足及缺乏三類；頸動脈狀態及冠狀動脈狀態分為正常及狹窄兩類。使用迴歸分析檢定維生素D狀態與頸動脈狀態及冠狀動脈狀態的相關性。結果：研究對象平均年齡為54.5歲(±0.47)、男性佔69.93%；65.39%維生素D異常、35.31%服用含維生素D補充品、35.14%頸動脈狹窄、79.94%冠狀動脈狹窄。控制其他變項後，相較於20-39歲，40至65歲及大於65歲，維生素D正常的機率比分別為15.93 (95% CI :3.54-71.69, P＝.0003)、63.06 (95% CI :11.57-343.82, P<.0001)；新陳代謝指數異常者，維生素D正常的機率為0.32 (95% CI: 0.16-0.23, P＝.0008)；有服用含維生素D補充品者，維生素D正常的勝算比為2.24 (95% CI: 1.30-3.86, P＝.0035)。維生素D不足者，頸動脈狹窄的勝算比為0.52 (95% CI: 0.33-0.8, P＝.0033)。維生素D狀態不是冠狀動脈狹窄顯著的預測因子。結論：自費健康檢查民眾，年齡較輕、新陳代謝指數異常者，血中維生素D異常的風險較高；血中維生素D正常和頸動脈狹窄呈正相關。建議年齡較輕、室內工作者、新陳代謝指數異常者、應增加紫外線暴露的機會並適當服用維生素D補充品。[[abstract]]Background: Cardiovascular disease has been the most top one cause of death worldwide for many years. Epidemiological studies have demonstrated that vitamin D is an independent risk factor of cardiovascular disease that were known to be associated with atherosclerosis. However, the correlation between vitamin D inadequate and atherosclerosis have reported contradictory result and no research in Taiwan.Objectives: The purpose of this study is to explore the correlation between serum level of vitamin D and atherosclerosis in physical examination individual of own payment in 2018.Methods: This is a cross- sectional study adopting secondary database. We performed on a sample of 527 whom done carotid ultrasound and 212 done Coronary Computed Tomography Angiography that were used to evaluate status of atherosclerosis. Vitamin D status is divided into three categories: normal, insufficiency and deficiency. Carotid artery status and coronary artery status are divided into normal and stenosis. We performed the regression model to determine the correlation status of vitamin D and atherosclerosisResults: The cross section analysis was performed from physical examination center in 2018.The basic data that mean age of 54.4 ±0.47, 69.93% of whom were man. The group of high prevalence of vitamin D inadequate was accounted 65.39 %. The group of prevalence of carotid stenosis and coronary artery stenosis were accounted 35.14% and 79.94%. The multivariate analysis, a test of statistical significant positive correlation of adjust odds ratio between whom took supplement of Vitamin D compare with no took that sufficient of vitamin D was 2.24 (95% CI: 1.30-3.86, P＝.0035). A test of statistical significant inverse correlation of adjust odds ratio between whom insufficient of Vitamin D compare with sufficient of vitamin D that carotid artery stenosis was 0.52 (95% CI: 0.33-0.8, P＝.0033). The Vitamin D status is not a predictor of Coronary artery stenosis. Conclusions: Vitamin D inadequate have higher odds of whom are younger and have no exercise habit and have metabolic syndrome. Carotid stenosis was a significant positive correlation of vitamin D status. Recommended that the younger people, who scarcely join outdoor activities and the ones who have metabolic syndrome should increase sun exposure and examine of vitamin D and intake rich food of vitamin D and vitamin D supplements appropriately