Molecular survival strategies of Echinococcus multilocularis in the murine host

  • Gottstein, Bruno
  • Haag, Karen
  • Walker, Mirjam
  • Matsumoto, Jun
  • Mejri, Naceur
  • Hemphill, Andrew
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Publication date
January 2006
Publisher
Elsevier BV
ISSN
1383-5769
Citation count (estimate)
26

Abstract

Larval infection with Echinococcus multilocularis starts with the intrahepatic postoncospheral development of a metacestode that-at its mature stage-consists of an inner germinal and an outer laminated layer (GL ; LL). In certain cases, an appropriate host immune response may inhibit parasite proliferation. Several lines of evidence obtained in vivo and in vitro indicate the important bio-protective role of the LL. For instance, the LL has been proposed to protect the GL from nitric oxide produced by periparasitic macrophages and dendritic cells, and also to prevent immune recognition by surrounding T cells. On the other hand, the high periparasitic NO production by peritoneal exsudate cells contributes to periparasitic immunosuppression, e...

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