Ageladine A: an antiangiogenic matrixmetalloproteinase inhibitor from the marine sponge Agelas nakamurai.
- Fujita, M
- Nakao, Y
- Matsunaga, S
- Seiki, M
- Itoh, Y
- Yamashita, J
- Van Soest, RW
- Fusetani, N
View in ORKG Publication date
December 2003
DOI Publisher
American Chemical Society (ACS) Journal
Journal of the American Chemical SocietyAbstract
A novel MMP inhibitor, ageladine A (1) with antiangiogenic activity was isolated from a marine sponge Agelas nakamurai. Structure 1 was determined by a combination of spectroscopic and chemical methods to be an unprecedented structure of 4-(4,5-dibromo-1H-pyrrol-2-yl)]-1H-imidazo[4,5-c]pyridin-2-amine