Tamoxifen (TAM) is a non-steroidal anti-estrogen used to treat patients with estrogen receptor-positive breast cancer and as a chemopreventive agent against breast cancer in high risk pre- and post-menopausal women. However, recent studies have shown that tamoxifen causes endometrial and hepatic cancer. In this study, we examined the effects of tamoxifen (5, 10, 25 and 50 microM) on the growth and proliferation of nine tumoral cell lines (UACC62, MCF-7, NCI-460, K-562, OVCAR-03, PC-03, HT-29, 786-0, NCI-ADR) and non-tumoral cell lines (3T3, V79, MDCK, VERO). Chinese hamster lung fibroblasts (V79) were the most sensitive lineage to tamoxifen, with 21.6% of the cells showing apoptosis at 50 microM TAM. Microscopic analysis showed that, the ce...
<p>Tamoxifen (Nolvadex) is one of the most widely used and effective therapeutic agent for breast ca...
<p>Tamoxifen (Nolvadex) is one of the most widely used and effective therapeutic agent for breast ca...
<p>Tamoxifen (Nolvadex) is one of the most widely used and effective therapeutic agent for breast ca...
Tamoxifen (TAM) is a non-steroidal anti-estrogen used to treat patients with estrogen receptor-posit...
Aim: To investigate the cytotoxic effects of tamoxifen on the breast cancer cell line (MCF7).Methods...
Tamoxifen, a potent anticancer agent known to interrupt the enhanced estrogen activity of malignant ...
Tamoxifen citrate (TAM) has been used to treat breast cancer in women for many years. The com-parati...
<p>(<b>A</b>) T47D human breast cancer cells but not MCF-7 cells expressed significant amount of CYP...
Anti-estrogen therapy is used for treatment of hormone (estrogen) receptor positive breast cancer. T...
Summary Previously we have shown that tamoxifen (TAM) induces morphological and biochemical changes ...
Tamoxifen remains a frontline treatment for hormone-responsive breast cancer despite its use being a...
Tamoxifen is an antiestrogen used in adjuvant therapy of breast carcinoma and could potentially prev...
Tamoxifen increases endometrial cell proliferation and the incidence of endometrial cancer in postme...
An in vitro study was conducted to determine the apoptosis induced by tamoxifen (TAM) and TAM-loaded...
We developed a three-dimensional assay prepared from primary breast cancer tissue and quantified tum...
<p>Tamoxifen (Nolvadex) is one of the most widely used and effective therapeutic agent for breast ca...
<p>Tamoxifen (Nolvadex) is one of the most widely used and effective therapeutic agent for breast ca...
<p>Tamoxifen (Nolvadex) is one of the most widely used and effective therapeutic agent for breast ca...
Tamoxifen (TAM) is a non-steroidal anti-estrogen used to treat patients with estrogen receptor-posit...
Aim: To investigate the cytotoxic effects of tamoxifen on the breast cancer cell line (MCF7).Methods...
Tamoxifen, a potent anticancer agent known to interrupt the enhanced estrogen activity of malignant ...
Tamoxifen citrate (TAM) has been used to treat breast cancer in women for many years. The com-parati...
<p>(<b>A</b>) T47D human breast cancer cells but not MCF-7 cells expressed significant amount of CYP...
Anti-estrogen therapy is used for treatment of hormone (estrogen) receptor positive breast cancer. T...
Summary Previously we have shown that tamoxifen (TAM) induces morphological and biochemical changes ...
Tamoxifen remains a frontline treatment for hormone-responsive breast cancer despite its use being a...
Tamoxifen is an antiestrogen used in adjuvant therapy of breast carcinoma and could potentially prev...
Tamoxifen increases endometrial cell proliferation and the incidence of endometrial cancer in postme...
An in vitro study was conducted to determine the apoptosis induced by tamoxifen (TAM) and TAM-loaded...
We developed a three-dimensional assay prepared from primary breast cancer tissue and quantified tum...
<p>Tamoxifen (Nolvadex) is one of the most widely used and effective therapeutic agent for breast ca...
<p>Tamoxifen (Nolvadex) is one of the most widely used and effective therapeutic agent for breast ca...
<p>Tamoxifen (Nolvadex) is one of the most widely used and effective therapeutic agent for breast ca...