Cytotoxicity Of Tamoxifen In Normal And Tumoral Cell Lines And Its Ability To Induce Cellular Transformation In Vitro.

  • Petinari, Leandro
  • Kohn, Luciana Konecny
  • de Carvalho, João Ernesto
  • Genari, Selma Candelária
ORKG logo View in ORKG
Publication date
November 2015
Publisher
Elsevier BV
Journal
Cell Biology International

Abstract

Tamoxifen (TAM) is a non-steroidal anti-estrogen used to treat patients with estrogen receptor-positive breast cancer and as a chemopreventive agent against breast cancer in high risk pre- and post-menopausal women. However, recent studies have shown that tamoxifen causes endometrial and hepatic cancer. In this study, we examined the effects of tamoxifen (5, 10, 25 and 50 microM) on the growth and proliferation of nine tumoral cell lines (UACC62, MCF-7, NCI-460, K-562, OVCAR-03, PC-03, HT-29, 786-0, NCI-ADR) and non-tumoral cell lines (3T3, V79, MDCK, VERO). Chinese hamster lung fibroblasts (V79) were the most sensitive lineage to tamoxifen, with 21.6% of the cells showing apoptosis at 50 microM TAM. Microscopic analysis showed that, the ce...

Extracted data

We use cookies to provide a better user experience.