Correlation of serum tumor necrosis factor-alpha, interleukin-4 and soluble interleukin-2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosis

WOS: 000182332700002PubMed: 12745543THE precise clinical manifestations of tuberculosis are likely to result from a complex interaction between the host and the pathogen. We took serum samples from a group of patients with a variety of clinical and radiological stages of pulmonary tuberculosis in order to characterize tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4) and soluble interleukin-2 receptor (sIL-2R) response. We further evaluated whether the levels of TNF-alpha, IL-4 and soluble IL-2R are related with each other, and also evaluated the levels of TNF-alpha, IL-4 and sIL-2R after anti-tuberculosis therapy and relation with radiologic scores. Forty-three inpatients with active pulmonary tuberculosis and 19 healthy controls participated in the study. Patients were divided into four categories radiologically on chest X-ray ( minimal, moderate-advanced, far-advanced and with miliary infiltration). Concentrations of TNF-alpha (20.9 +/- 10/15.4 +/- 8 pg/ml) and sIL-2R (2569 +/- 842/1444 +/- 514 pg/ml) were statistically different between patients and controls ( p = 0.02 and p = 0.0001, respectively). Before chemotherapy there was a positive correlation between TNF-alpha and sIL-2R (r = 0.34), but there was no correlation between IL-4 and TNF-alpha, and between IL-4 and sIL-2R (r = -0.23 and r = -0.22). The TNF-alpha level was not statistically different in four groups before and after chemotherapy. Results of this study provided some evidence confirming the previously reported role of TNF-alpha, IL-4 and sIL 2R in the control of tuberculosis, but these cytokines were not found related with disease severity