A series of base-modified pyrimidine 3'-azido-2',3'-dideoxynucleosides and 3'-substituted purine and pyrimidine 2',3'-dideoxynucleosides have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV) replication in MT-4 cells. The following pyrimidine derivatives emerged as the most potent and/or selective inhibitors of HIV-induced cytopathogenicity (in order of decreasing selectivity: 3'-azido-3'-deoxythymidine (AZT), 3'-azido-2',3'-dideoxyuridine (AzddUrd), 3'-azido-2',3'-dideoxy-5-methylcytidine (AzddMeCyd), 3'-fluoro-ddUrd (FddUrd), 3'-fluoro-ddThd (FddThd), the N4-hydroxylated derivative of AzddMeCyd and the N4-methylated derivative of AzddMeCyd. Among the purine 2',3'-dideoxynucleosides, 3...
We report the synthesis of a family of d- and l-furano-d-apionucleosides, their 3'-deoxy, as well as...
The novel 5-chloro-, 5-bromo-, and 5-iodo-derivatives of 3'-fluoro-2',3'-dideoxyuridine (FddUrd), de...
The 4-substituted pyrimidine 2′,3′-dideoxy-2′,3′-didehydronucleosides 3 - 10 have been synthesized a...
A series of 2',3'-unsaturated and 3'-substituted 2',3'-dideoxynucleoside analogues of purines and py...
To decrease the toxicity of potent anti-HIV nucleosides 3'-azido-2',3'-dideoxythymidine (AZT) and 2'...
Several sugar-modified 2,6-diaminopurine and guanine 2',3'-dideoxyribosides were synthesized and eva...
A series of 2'- and 3'-fluorinated 2',3'-dideoxynucleosides and 3'-azido-2',3'-dideoxynucleosides we...
5'-O-Phosphonomethylation of different pyrimidine 2',3'-dideoxynucleosides was accomplished by react...
The 3'-fluoro-and 3'-azido-substituted derivatives of 2',3'-dideoxythymidine (ddThd), 2',3'-dideoxyu...
About 40 new 2',3'-dideoxynucleoside analogues with different basic structures have been synthetized...
The pyrimidine nucleus is a versatile core in the development of antiretroviral agents. On this basi...
A series of the novel pyrimidine (3-6) and purine (12-15, 18-21) acyclic nucleoside analogues in whi...
The pyrimidine nucleus is a versatile core in the development of antiretroviral agents. On this basi...
2′,3′-Dideoxyguanosine (ddG) is a nucleoside analogue that has been found to exert a relatively mode...
A systematic synthesis was undertaken of 2',3'-dideoxyadenosine analogues with either an azido, fluo...
We report the synthesis of a family of d- and l-furano-d-apionucleosides, their 3'-deoxy, as well as...
The novel 5-chloro-, 5-bromo-, and 5-iodo-derivatives of 3'-fluoro-2',3'-dideoxyuridine (FddUrd), de...
The 4-substituted pyrimidine 2′,3′-dideoxy-2′,3′-didehydronucleosides 3 - 10 have been synthesized a...
A series of 2',3'-unsaturated and 3'-substituted 2',3'-dideoxynucleoside analogues of purines and py...
To decrease the toxicity of potent anti-HIV nucleosides 3'-azido-2',3'-dideoxythymidine (AZT) and 2'...
Several sugar-modified 2,6-diaminopurine and guanine 2',3'-dideoxyribosides were synthesized and eva...
A series of 2'- and 3'-fluorinated 2',3'-dideoxynucleosides and 3'-azido-2',3'-dideoxynucleosides we...
5'-O-Phosphonomethylation of different pyrimidine 2',3'-dideoxynucleosides was accomplished by react...
The 3'-fluoro-and 3'-azido-substituted derivatives of 2',3'-dideoxythymidine (ddThd), 2',3'-dideoxyu...
About 40 new 2',3'-dideoxynucleoside analogues with different basic structures have been synthetized...
The pyrimidine nucleus is a versatile core in the development of antiretroviral agents. On this basi...
A series of the novel pyrimidine (3-6) and purine (12-15, 18-21) acyclic nucleoside analogues in whi...
The pyrimidine nucleus is a versatile core in the development of antiretroviral agents. On this basi...
2′,3′-Dideoxyguanosine (ddG) is a nucleoside analogue that has been found to exert a relatively mode...
A systematic synthesis was undertaken of 2',3'-dideoxyadenosine analogues with either an azido, fluo...
We report the synthesis of a family of d- and l-furano-d-apionucleosides, their 3'-deoxy, as well as...
The novel 5-chloro-, 5-bromo-, and 5-iodo-derivatives of 3'-fluoro-2',3'-dideoxyuridine (FddUrd), de...
The 4-substituted pyrimidine 2′,3′-dideoxy-2′,3′-didehydronucleosides 3 - 10 have been synthesized a...