PROTECTIVE EFFECTS OF MOUTAN CORTEX RADICIS AGAINST ACUTE HEPATOTOXICITY

  • Park, Juhyun
  • Kim, Hyo-Yeon
  • Lee, Sun-Mee
Publication date
May 2011
Publisher
African Traditional, Herbal Medicine Supporters Initiative (ATHMSI)

Abstract

This study evaluated the potential beneficial effect of Moutan Cortex Radicis (MCR) in a murine model of carbon tetrachloride (CCl4)-, D-galactosamine (GalN)- and α-naphthylisothiocyanate (ANIT)-induced liver injury. Acute hepatotoxicity was induced by intraperitoneal injection of CCl4 (10 μL/kg), GalN (700 mg/kg), and ANIT (40 mg/kg). Animals received MCR (30, 100, and 300 mg/kg ) orally at 48, 24, and 2 h before and 6 h after administration of CCl4, GalN, and ANIT. Serum activities of aminotransferase were significantly higher at 24 h after CCl4 or GalN treatment. These changes were attenuated by MCR. Histopathological analysis revealed multiple and extensive areas of portal inflammation, hepatocellular necrosis, and an increase in infl...

Extracted data

We use cookies to provide a better user experience.