Application of prothrombin complex concentrate for reversal of direct oral anticoagulants in clinical practice: indications, patient characteristics and clinical outcomes compared to reversal of vitamin K antagonists.

  • Müller, Martin
  • Eastline, Jonathan
  • Nagler, Michael
  • Exadaktylos, Aristomenis K.
  • Sauter, Thomas C.
Publication date
April 2019
Publisher
Springer Science and Business Media LLC

Abstract

BACKGROUND Prothrombin complex concentrate (PCC) is widely used to reverse the action of direct oral anticoagulants (DOACs) in accordance with current guidelines and because of a lack of specific reversal agents. Indications, clinical characteristics and patient outcomes of patients might differ in comparison to reversal of vitamin K antagonists where reversal with PCC is well established. METHODS Our cohort study explores patient characteristics, indications and clinical outcomes for reversal of all DOAC patients receiving PCC at our university emergency department from 01.06.2012 to 01.07.2017, in comparison with patients on VKA. RESULTS Out of 199,982 consultations, we studied 346 patients who were given PCC for reversal o...

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